Topics
- Precongress John Humphrey Advance Immunology Course.
Glauber Rocha, Havana, March 19-22, 2012
Allergen Vaccines
- Immunology and Molecular Allergology symposium:
- Progress in novel allergen vaccines, recombinant allergens.
- Modified versus non modified allergen vaccines.
- Allergen structure and function.
- Adjuvants for allergen vaccines.
- Mucosal routes and immunity.
- Interaction of allergens with innate immunity.
- Allergy and parasitism: relevance to allergen and parasitic vaccines.
- Pharmaceutical development symposium:
- Analytical development, potency and major allergen assays, reference system.
- Challenges in stability studies, ICH compliance.
- Formulation development, injections and sublingual route.
- Quality issues and process development, validation, natural and recombinant products.
- Allergen standardization and Regulatory problems symposium:
- Centralized Registration of Allergen Products in Europe.
- Regulatory Approach to Allergen Products in USA.
- Developing the Regulatory Status of allergen products in Latin America.
- Clinical Trials symposium:
- Design of clinical trials: efficacy endpoints, immunological markers, provocation tests, confirmatory studies.
- Preliminary, phase I, and dose-finding studies.
- Long-term efficacy markers, immunological memory mechanisms.
- Safety, pharmacovigilance studies
- Clinical Trials in children
- Special WAO-AAAAI Symposium on Subcutaneous Immunotherapy (R. Lockey, D. Ledford, USA):
- Practice parameters.
- Cost-effectiveness of SCIT.
- Efficacy and immunologic changes included by SCIT.
- Allergome Platform Course for Molecular Allergologists (Prof. Adriano Mari, Italy).
Adjuvants
- New generation of adjuvants:
- Immunobiology of adjuvants, immune activation.
- Immunological mechanisms: long-lived memory T-cell induction, Th-1/Th-2 cell polarization.
- Microbe-derived immunostimulants (TLR agonist, CpG, etc).
- Particulate immunostimulants (VLPs, oil-in-water, PLGA,etc).
- Synthetic molecules.
- Adjuvants to Influenza Vaccines and other Respiratory Diseases:
- pandemic and seasonal.
- friendly platform of immunization.
- intradermal, skin delivery, microneedle immunization.
- Adjuvants to Sexually Transmitted Infections:
- Genital herpes, chlamyda, chancroid, HIV, etc.
- Mucosal responses and immunity.
- Adjuvants to Allergy Vaccines:
- Sublingual, subcutaneous, intradermal immunization.
- Skin delivery.
- TLR, mucosal routes and immunity.
- Adjuvants to Tuberculosis Vaccines:
- Mucosal adjuvants.
- Micobacterial TLR ligands.
- Micro or nanoparticles, Cationic lipids.
- Adjuvants combinations and delivery.
- Adjuvants to anti-Parasite Vaccines:
- Leishmania, malaria and Schistosoma and other.
- Adjuvants to Cancer Vaccines:
- Cytokines, dendritic cells.
- Strategies to polarize the immune response.
- Effector and memory T cells.
- Therapeutic efficacy against tumors.
- Adjuvants in Veterinary Vaccinology:
- Animal species.
- Route of immunization.
- Type of immunity needed.
- Immunotoxicology.
